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Chemopreventive Effects of Black Tea Polyphenols in Mose Skin Model of Carcinogenesis

In the present investigations,the antitumorigenic effect of black tea polyhenols(BTP)in two-stage mouse skin model of carcinogenesis was studied.The animals were initated with a single“subcarcinogenic”topical dose(52μg/200μl acetone)of 7,12-dimethylbenzanthracene(DMBA).To evaluate the anti-tumour initiating activity,BTP was topically appied twice a week for three weeks prior to DMBA applications,followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate(TPA)(5μg/200μl acetone,2x/wk.)as promoter.For eveluation of antitumor prmotin activity,BTP was applied prior to each treatment of TPA.BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin model o two-stage carcinogenesis.Since initiation involves genetic pathway and tumour prmotion involves epigenetic pathway,it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic pathways.

完成机构：LaboratoryofEnvironmentalCarcinogenesis,IndustrialToxicologyResearchCentre,M.G.Marg,P.O.Box80,Lucknow

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