当前位置：
首页 >
资讯 >
茶叶知识> 正文
（—）Epicatechin induces and modulates endotheliumdependent relaxation in isolated rat mesenteric arte
2021-02-22 16:20:49热度:159°C
AIM:The present study was aimed to examine the role of endothelial nitric oxide in the relaxant response to green tea (-)epicatechin and its modulation of endothelium-mediated relaxation in the isolated rat mesenteric artery rings.METHODS:Changes in the isometric tension were measured with Grass force-displacement transducers.RESULTS:The (-)epicatechin-induced relaxation was largely dependent on the presence of intact endothelium and was reversed by N^G-nitro-L-arginine methyl ester 10μmol/L or methylene blue 10μmol/L，the inhibitors of nitric oxidemediated relaxation.L-Arginine at 1mmol/L antagonized the effect of L-NAME or methylene blue.Pretreatment of endothelium-intact rings with (-)epicatechin 10μmol/L enhanced the relaxation induced by endothelium-dependent vasodilator,acetylcholine,while this concentration did not influence the endothelium-independent relaxation induced by sodium nitroprusside in the endothelium-denuded artery rings.CONCLUSION:The results indicate that the endothelium-dependent vasodilation by (-)epicatechin is mainly mediated through nitric oxide and low concentration of (-)epicatechin augments endothelium-dependent vasorelaxation in the rat mesenteric arteries.
完成机构：[1]DepartmentofBiochemistry,ChineseUniversityofHongKong,China [2]DepartmentofPhysiology,ChineseUniversityofHongKong,China
十大品牌
茶叶茶叶大市场
相关文章
SQL Error: select id,classid,MATCH(title) AGAINST('03080110 01100309 Epicatechin induces an' IN BOOLEAN MODE) as jhc from ***_enewssearchall where (id<>218430) and MATCH(title) AGAINST('03080110 01100309 Epicatechin induces an' IN BOOLEAN MODE) order by jhc desc,infotime desc limit 0, 6
